CSI: New York, the third incarnation of the CSI: Crime Scene Investigation franchise, is a crime drama about forensic investigators who use high-tech science to follow the evidence and solve crimes in The Big Apple. Detective Mack "Mac" Taylor is a dedicated and driven crime scene investigator who believes that everything is connected and for everyone there is a story. He and his partner, Detective Stella Bonasera, a workaholic and a jack-of-all-trades, share a passion for the job. They lead a team of experts amid the gritty and kinetic city that never sleeps. Their team includes Danny Messer, a Brooklyn-born investigator with rugged good looks, an unflappable spirit and a colorful family history, and Dr. Sheldon Hawkes, a reclusive coroner who walked away from a promising surgical career after the traumatic loss of two patients. Joining them is homicide Detective Don Flack, an edgy, hardcore investigator with a quick wit, impressive forensic insight and limited patience with potential suspects. Rounding out the team is Aiden Burn, a smart and sexy investigator whose chameleon-like behavior allows her to adapt to any situation at any time. These skilled investigators, who see New York City in a whole different light, follow the evidence as they piece together clues and eliminate doubt to ultimately crack their cases.

　　由于丈夫的意外死亡，单亲母亲Nancy Botwin（玛丽·露易斯·帕克 Mary-Louise Parker 饰）成了一名膝下抚有两子的单身母亲，一无所长的她找不到一份能养活一家三口的工作，为维持家里的生计她选择了在所住的富人区里贩卖大麻，虽然收益丰厚，却也风险不小。大儿子Silas（亨特·帕瑞施 Hunter Parrish 饰）正处青春期，叛逆不羁。小儿子Shane（亚历山大·古尔德 Alexander Gould 饰）有点孤僻，不合群。最糟糕的是小叔子Andy （贾斯汀·柯克 Justin Kirk 饰）还寄住家中总是胡作非为。Nancy在贩大麻的同时还要辛苦躲避她的孩子，亲友，还有她的好友Celia（伊丽莎白·帕金斯 Elizabeth Perkins  饰），于是闹出了一连串啼笑皆非的事……

　　《CSI》的故事背景设在赌城拉斯维 加斯，以真人真事改编，讲述刑事警察局的法庭犯罪调查员如何在作案现场取得证据破案的故事。调查员的名言是“死尸会说话”，他们利用指纹、鞋印、子弹壳、血迹、毛发、纤维、尸体伤痕等微小证据，经过仔细的分析研究后，寻得破案的关键。
　　解开谜团的过程颇有吸引力。此剧还重建死者被害时的现场，拍摄子弹如何在体内穿梭，血管、器官被破坏过程，逼真景观令人屏息。看了如此细致的破案手法，即使有犯罪的胆在以身试法时也要好好考虑。
　　这部美国哥伦比亚广播公司的王牌节目，曾获得第59届美国金球奖“最佳系列剧”，主演过《异形》的海尔金伯格凭该剧获得了最佳女主角奖。另外，该节目还获艾美奖六项提名，入选2002年美国“十大最佳电视影集”、美国CBS电视台当年收视冠军，可谓集三千宠爱于一身。
　　该节目比传统刑事案件报道更有情节性和悬念性。《CSI》的专职顾问伊丽莎白·德瓦恩是一位曾在洛杉矶安全部门供职长达15年的犯罪现场调查人。该节目收视率之所以居高不下，41岁的德瓦恩功不可没。另外，《CSI》已成为美国警方的必备学习教材，连英国苏格兰场、日本警卫厅以及法国警局都视之为反恐教材。